Journal of Biomechanics
Volume 38, Issue 9 , Pages 1838-1845 , September 2005

Cellular accommodation and the response of bone to mechanical loading

  • Jennifer L. Schriefer

      Affiliations

    • Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA
    • ,
  • Stuart J. Warden

      Affiliations

    • Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USA
    • Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    • ,
  • Leanne K. Saxon

      Affiliations

    • Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    • ,
  • Alexander G. Robling

      Affiliations

    • Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    • ,
  • Charles H. Turner

      Affiliations

    • Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    • Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis, IN, USA
    • Corresponding Author InformationCorresponding author. Indiana University, 1120 South Dr., FH 115, Indianapolis, IN 46202, USA. Tel: +1-317-274-3226; fax: +1-317-278-9568.

,Accepted 17 August 2004.

References 

  1. Beaupré GS, Orr TE, Carter DR. An approach for time-dependent bone modeling and remodeling-theoretical development. Journal of Orthopaedic Research. 1990;8:651–661
  2. Bertram JEA, Biewener AA. Bone curvature (sacrificing strength for load predictability?). Journal of Theoretical Biology. 1988;131:75–92
  3. Cowin SC, Hegedus DH. Bone remodeling I (theory of adaptive elasticity). Journal of Elasticity. 1976;6:313–326
  4. Frost HM. A determinant of bone architecture (the minimum effective strain). Clinical Orthopaedics. 1983;175:286–292
  5. Fyhrie DP, Schaffler MB. The adaptation of bone apparent density to applied load. Journal of Biomechanics. 1995;28:135–146
  6. Hsieh Y-F, Turner CH. Effects of loading frequency on mechanically induced bone formation. Journal of Bone and Mineral Research. 2001;16:918–924
  7. Kim CH, Takai E, Zhou H, von Stechow D, Müller R, Dempster DW, et al. Trabecular bone response to mechanical and parathyroid hormone stimulation (the role of mechanical microenvironment). Journal of Bone and Mineral Research. 2003;18:2116–2125
  8. Lanyon LE. The success and failure of the adaptive response to functional load-bearing in averting bone fracture. Bone. 1992;13(Suppl.):S17–S21
  9. Martin RB. Porosity and specific surface of bone. Critical Reviews in Biomedical Engineering. 1984;10:179–222
  10. McKee MD, Nanci A. Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants (ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair). Microscopy Research Techniques. 1996;33:141–164
  11. Meyer GH. Die architektur der spongiosa. Archiv für Anatomie, Physiologie und wissenschaftliche Medicin. 1867;34:615–625
  12. Pavalko FM, Chen NX, Turner CH, Burr DB, Atkinson S, Hsieh Y-F, et al. Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions. American Journal of Physiology. 1998;275:C1591–C1601
  13. Robling AG, Burr DB, Turner CH. Recovery periods restore mechanosensitivity to dynamically loaded bone. The Journal of Experimental Biology. 2001;204:3389–3399
  14. Robling AG, Hinant FM, Burr DB, Turner CH. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. Journal of Bone and Mineral Research. 2002;17:1545–1554
  15. Robling AG, Hinant FM, Burr DB, Turner CH. Shorter, more frequent mechanical loading sessions enhance bone mass. Medicine and Science Sports and Exercise. 2002;34:196–202
  16. Rubin C, Judex S, Hadjiargyrou M. Skeletal adaptation to mechanical stimuli in the absence of formation or resorption of bone. Journal of Musculoskeletal and Neuronal Interactions. 2002;2:264–267
  17. Saxon, L.K., Robling, A.G., Turner, C.H., 2004. A long period of rest between sessions of mechanical loading may improve bone strength. In: Transactions of the Orthopaedic Research Society. San Francisco, CA.
  18. Turner CH. Toward a mathematical description of bone biology (the principle of cellular accommodation). Calcified Tissue International. 1999;65:466–471
  19. Turner CH, Forwood MR, Rho J, Yoshikawa T. Mechanical loading thresholds for lamellar and woven bone formation. Journal of Bone and Mineral Research. 1994;9:87–97
  20. Torrance AG, Mosley JR, Suswillo RF, Lanyon LE. Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periosteal pressure. Calcified Tissue International. 1994;54:241–247
  21. Wolff J. Das Gesetz der Transformation der Knochen. Berlin: Hirschwald; 1892;

PII: S0021-9290(04)00412-9

doi: 10.1016/j.jbiomech.2004.08.017

Journal of Biomechanics
Volume 38, Issue 9 , Pages 1838-1845 , September 2005

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