Journal of Biomechanics
Volume 38, Issue 9 , Pages 1789-1797 , September 2005

Nanomechanics of opposing glycosaminoglycan macromolecules

  • Joonil Seog

      Affiliations

    • Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MIT 13-4022, Cambridge, MA 02139, USA
    • Present address: The CBR Institute for Biomedical Research, Inc., Harvard Medical School, Boston, MA 02115, USA.
    • ,
  • Delphine Dean

      Affiliations

    • Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MIT 13-4022, Cambridge, MA 02139, USA
    • ,
  • Bernd Rolauffs

      Affiliations

    • Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MIT 13-4022, Cambridge, MA 02139, USA
    • ,
  • Tao Wu

      Affiliations

    • Riddick Laboratories, Department of Chemical Engineering, North Carolina State University, Raleigh, NC 27695-7905, USA
    • Present address: National Institute of Standards and Technology, Polymers Division, Polymers Building (224), Room B228, 100 Bureau Drive, Stop 8546, Gaithersburg, MD 20899-8546, USA.
    • ,
  • Jan Genzer

      Affiliations

    • Riddick Laboratories, Department of Chemical Engineering, North Carolina State University, Raleigh, NC 27695-7905, USA
    • ,
  • Anna H.K. Plaas

      Affiliations

    • Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida, Tampa, FL 33620, USA
    • ,
  • Alan J. Grodzinsky

      Affiliations

    • Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MIT 13-4022, Cambridge, MA 02139, USA
    • Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MIT 13-4022, Cambridge, MA 02139, USA
    • Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MIT 13-4022, Cambridge, MA 02139, USA
    • ,
  • Christine Ortiz

      Affiliations

    • Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MIT 13-4022, Cambridge, MA 02139, USA
    • Corresponding Author InformationCorresponding author. Tel.: +16174523084; fax: +16174523085.

,Accepted 6 September 2004.

References 

  1. Bathe M, Rutledge GC, Grodzinsky AJ, Tidor B. Towards a multi-scale model of cartilage (coarse-graining glycosaminoglycans). In:  Bathe KJ editors. Second MIT Conference on Computational Fluid and Solid Mechanics. Cambridge, MA: Elsevier; 2003;p. 1626–1630
  2. Buckwalter JA, Mankin HJ. Instructional course lectures, the American Academy of Orthopaedic Surgeons—articular cartilage. Part I (Tissue design and chondrocyte–matrix interactions). Journal of Bone and Joint Surgery, American Volume. 1997;79:600–611
  3. Buckwalter JA, Mankin HJ. Instructional course lectures, the American Academy of Orthopaedic Surgeons—articular cartilage. Part II (Degeneration and osteoarthrosis, repair, regeneration, and transplantation). Journal of Bone and Joint Surgery, American Volume. 1997;79:612–632
  4. Buschmann MD, Grodzinsky AJ. A molecular model of proteoglycan-associated electrostatic forces in cartilage mechanics. Journal of Biomechanical Engineering. 1995;117(2):179–191
  5. Calabro A, Midura RJ, Wang A, West LA, Plaas AHK, Hascall VC. Fluorophore-assisted carbohydrate electrophoresis (FACE) of glycosaminoglycans. Osteoarthritis and Cartilage. 2001;9(SA):S16–S22
  6. Cowman MK, Lin M, Balazs EA. Tapping mode atomic force microscopy of hyaluronan (Extended and intramolecularly interacting chains). Biophysical Journal. 1998;75:2030–2037
  7. Dean D, Seog J, Ortiz C, Grodzinsky AJ. A new molecular-level theoretical model for the electrostatic interactions between polyelectrolyte macromolecules using glycosaminoglycans as a model system. Langmuir. 2003;19(13):5526–5539
  8. Eisenberg SR, Grodzinsky AJ. Swelling of articular cartilage and other connective tissues (Electromechanochemical forces). Journal of Orthopaedic Research. 1985;3(2):148–159
  9. Evans E. Probing the relation between force-lifetime and chemistry in single molecular bonds. Annual Review of Biophysical and Biomolecular Structure. 2001;30:105–128
  10. Ferguson VL, Bushby AJ, Boyde A. Nanomechanical properties and mineral concentration in articular calcified cartilage and subchondral bone. Journal of Anatomy. 2003;203(2):191–202
  11. Frank EH, Grodzinsky AJ, Phillips SL, Grimshaw PE. Physicochemical and bioelectrical determinants of cartilage material properties. In:  Mow VC,  Ratcliffe A,  Woo SL-Y editor. Biomechanics of Diarthrodial Joints. New York: Springer; 1990;p. 261–282
  12. Freeman WDSC, Maroudas A. Charged group behaviour in cartilage proteoglycans in relation to pH. Annals of the Rheumatic Diseases. 1975;34:44–45
  13. Fujii T, Sun YL, An KN, Luo ZP. Mechanical properties of single hyaluronan molecules. Journal of Biomechanics. 2002;35(4):527–531
  14. Hoh JH, Engel A. Friction effects on force measurements with an atomic force microscope. Langmuir. 1993;9:3310–3312
  15. Hunziker PR, Stolz M, Aebi U. Nanotechnology in medicine (moving from the bench to the bedside). Chimia. 2002;56(10):520–526
  16. Hutter JL, Bechhoefer J. Calibration of atomic-force microscope tips. Journal of Review of Scientific Instruments. 1993;64:1868–1873
  17. Kovach IS. The importance of polysaccharide configurational entropy in determining the osmotic swelling pressure of concentrated proteoglycan solution and the bulk compressive modulus of articular cartilage. Biophysical Chemistry. 1995;53:181–187
  18. Kuettner KK. Articular Cartilage and Osteoarthritis. Philadelphia, PA: Lippincott Williams & Wilkins; 1992;
  19. Kuettner K, Lindenbaum A. Analysis of mucopolysaccharides in partially aqueous media. Biochimica et Biophysica Acta. 1965;101:223–225
  20. Lai WM, Hou JS, Mow VC. A triphasic theory for the swelling and deformation behaviors of articular cartilage. Journal of Biomechanical Engineering. 1991;113:245–258
  21. Liu X, Noble PC, Luo ZP. A method for testing compressive properties of single proteoglycan aggregates. Biochemical and Biophysical Research Communications. 2003;307(2):338–341
  22. Maroudas A. Balance between swelling pressure and collagen tension in normal and degenerate cartilage. Nature. 1976;260:808–809
  23. Mow V, Guo XE. Mechano-electrochemical properties of articular cartilage (Their inhomogeneities and anisotropies). Annual Review of Biomedical Engineering. 2002;4:175–209
  24. Ng LJ, Plaas AHK, Sandy JD, Grodzinsky AJ, Ortiz C. Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy. Journal of Structural Biology. 2003;143(3):242–257
  25. Ogston AG. In:  Balazs EA editors. Chemistry and Molecular Biology of the Intercellular Matrix. New York: Academic Press; 1970;p. 1231–1240
  26. Raspanti M, Congiu T, Guizzardi S. Tapping-mode atomic force microscopy in fluid of hydrated extracellular matrix. Matrix Biology. 2001;20:601–604
  27. Sasaki N, Odajima S. Elongation mechanism of collagen fibrils and force–strain relations of tendon at each level of structural hierarchy. Journal of Biomechanical Engineering. 1996;29:1131–1136
  28. Seog J, Dean D, Plaas AHK, Wong-Palms S, Grodzinsky AJ, Ortiz C. Direct measurement of glycosaminoglycan intermolecular interactions via high-resolution force spectroscopy. Macromolecules. 2002;35(14):5601–5615
  29. Seog J, Dean D, Frank E, Ortiz C, Grodzinsky AJ. Preparation of end-grafted polyelectrolytes on nanoscale probe tips using an electric field. Macromolecules. 2004;37(3):1156–1158
  30. Soulhat J, Buschmann MD, Shirazi-Adl A. A fibril network reinforced biphasic model of cartilage in uniaxial compression. Journal of Biomechanical Engineering. 1999;121:340–347
  31. Sun YL, Luo ZP, Fertala A, An KN. Direct quantification of the flexibility of type I collagen monomer. Biochemical and Biophysical Research Communication. 2002;295(2):382–386
  32. Treppo S, Koepp H, Quan EC, Cole AA, Kuettner KE, Grodzinsky AJ. Comparison of biomechanical and biochemical properties of cartilage from human knee and ankle. Journal of Orthopaedic Research. 2000;18:739–748
  33. Williamson A, Chen A, Sah R. Compressive properties and function-composition relationships of developing bovine articular cartilage. Journal of Orthopaedic Research. 2001;19:1113–1121
  34. Wu T, Efimenko K, Vlcek P, Subr V, Genzer J. Formation and properties of anchored polymers with a gradual variation of grafting densities on flat substrates. Macromolecules. 2003;36:2448–2453

PII: S0021-9290(04)00437-3

doi: 10.1016/j.jbiomech.2004.09.010

Journal of Biomechanics
Volume 38, Issue 9 , Pages 1789-1797 , September 2005

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