Length-dependent [Ca²⁺] sensitivity adds stiffness to muscle

Abstract 

It is well documented that muscle fibers become more sensitive for [Ca²⁺] with increasing sarcomere length. In mechanical terms this length-dependent [Ca²⁺] sensitivity (LDCS) adds to the stiffness of muscle fibers, because muscle force, normalized for the force–length relationship at maximal stimulation, increases with contractile element (CE) length. Although LDCS is well-documented in the physiological literature, it is ignored in most motor control studies. The aim of the present study was to investigate the importance of LDCS as a contributor to the stiffness of a muscle. Comparison of experimental data with predictions derived from the model of activation dynamics proposed by Hatze (Myocybernetic Control Models of Skeletal Muscle, University of South Africa, Pretoria, 1981, pp. 31–42) indicated that this model captures the main characteristics of LDCS well. It was shown that LDCS accounts for the experimentally observed shifts in optimum length at sub-maximal stimulation levels. Furthermore, it was shown that in conditions with low-to-medium muscle stimulation, the contribution of LDCS to the total amount of stiffness provided by the muscle is substantial. It was concluded that LDCS is an important muscle property and should be taken into account in studies concerning motor control.

Keywords: Activation dynamics, Stabilizing muscle property, Muscle modeling, Force–length relationship