Journal of Biomechanics
Volume 40, Issue 1 , Pages 36-45 , 2007

Tensile behavior of cortical bone: Dependence of organic matrix material properties on bone mineral content

  • S.P. Kotha

      Affiliations

    • Biomedical Engineering Department, Rutgers University, 617 Bowser Road, Piscataway, NJ 08854, USA
    • Present Address: Department of Oral Biology, University of Missouri – Kansas City, Rm 432 650 E. 25th St., Kansas City, MO 64108.
    • ,
  • N. Guzelsu

      Affiliations

    • Biomedical Engineering Department, Rutgers University, 617 Bowser Road, Piscataway, NJ 08854, USA
    • University of Medicine and Dentistry of New Jersey − SOM – Biomechanics Laboratory, Science Center, 2 Medical Center Drive, Stratford, NJ 08084-1504, USA
    • Corresponding Author InformationCorresponding author. Department of Osteosciences/Biomechanics Program, UDP-Suite 1700, 42 East Laurel Road, Stratford, NJ 08084-1504, USA. Tel.: +18565662731; fax: +18565662733.

,Accepted 26 November 2005.

References 

  1. Boccaccini AR, Ondracek G, Mombello E. Determination of stress concentration factors in porous materials. Journal of Materials Science Letters. 1996;14:534–536
  2. Bonar LC, Lees S, Mook HA. Neutron diffraction studies of collagen in fully mineralized bone. Journal of Molecular Biology. 1985;181:261–270
  3. Bowman SM, Zeind J, Gibson LJ, Hayes WC, McMahon TA. The tensile behavior of demineralized bovine cortical bone. Journal of Biomechanics. 1996;29:1497–1501
  4. Catanese J, Iverson EP, Ng RK, Keaveny TM. Heterogeneity of the mechanical properties of demineralized bone. Journal of Biomechanics. 1999;32:1365–1369
  5. Christiansen DL, Huang EK, Silver FH. Assembly of type I collagen: fusion of fibril subunits and the influence of fibril diameter on mechanical properties. Matrix Biology. 2000;19:409–420
  6. DePaula CA, Absornson C, Pan Y, Kotha SP, Koike K, Guzelsu N. Changing the structurally effective mineral content of bone with in-vitro fluoride treatment. Journal of Biomechanics. 2002;35:355–361
  7. Fondrk MT, Bahniuk EH, Davy DT. A damage model for nonlinear tensile behavior of cortical bone. Journal of Biomechanical Engineering. 1999;121:533–541
  8. Gao H, Ji B, Jager IL, Artz E, Fratzl P. Materials become insensitive to flaws at nanoscale: lessons from nature. Proceedings of the National Academy of Science. 2003;100:5597–5600
  9. Gilmore RS, Katz JL. Elastic properties of apatites. Journal of Material Science. 1982;17:1131–1141
  10. Hellmich C, Ulm FJ. Are mineralized tissues open crystal foams reinforced by crosslinked collagen?—Some energy arguments. Journal of Biomechanics. 2002;35:1199–1212
  11. Hellmich C, Ulm FJ, Dormieux L. Can the diverse elastic properties of trabecular and cortical bone be attributed to only a few tissue-independent phase properties and their interactions? Arguments from a multiscale approach. Biomechanics and Modeling in Mechanabiology. 2004;3:219–238
  12. Jager I, Fratzl P. Mineralized collagen fibrils: a mechanical model with staggered arrangement of mineral particles. Biophysical Journal. 2000;79:1737–1746
  13. Ji B, Gao H. Mechanical properties of nanostructure of biological materials. Journal of Mechanics and Physics of Solids. 2004;52:1963–1990
  14. Kotha SP, Guzelsu N. The effects of interphase and bonding on elastic modulus of bone: changes with age-related osteoporosis. Medical Engineering and Physics. 2000;22:575–585
  15. Kotha SP, Guzelsu N. Modeling the tensile mechanical behavior of bone along the longitudinal direction. Journal of Theoretical Biology. 2002;219:269–279
  16. Kotha SP, Guzelsu N. Effect of bone mineral content on the tensile properties of cortical bone: experiments and theory. Journal of Biomechanical Engineering. 2003;125:785–793
  17. Kotha SP, Guzelsu N. Tensile damage and its effects on cortical bone. Journal of Biomechanics. 2003;36:1683–1689
  18. Kotha SP, Kotha S, Guzelsu N. A shear lag model to account for the interaction effects between inclusions in rectangular platelet reinforced composites. Composite Science and Technology. 2000;60:2147–2158
  19. Kotha SP, Walsh WR, Pan Y, Guzelsu N. Varying the mechanical properties of bone tissue by changing the amount of its structurally effective bone mineral content. Bio-Medical Materials Engineering. 1998;8:321–334
  20. Kotha SP, Li Y, Guzelsu N. Micromechanical model of nacre tested in tension. Journal of Material Science. 2001;36:2001–2007
  21. Lees S. A mixed packing model for bone collagen. Calcified Tissue International. 1981;33:591–602
  22. Lees S. Mineralization of type I collagen. Biophysical Journal. 2003;85:204–207
  23. Li B, Aspden RM. Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis and osteoarthritis. Annals of Rheumatic Disorders. 1997;12:641–651
  24. McCutchen CW. Do mineral crystals stiffen bone by straitjacketing its collagen?. Journal of Theoretical Biology. 1975;51:51–58
  25. Pan HH, Weng GJ. Elastic moduli of heterogenous solids with ellipsoidal inclusions and elliptic cracks. Acta Mechanica. 1995;110:73–94
  26. Pins GD, Christiansen DL, Patel R, Silver FH. Self-assembly of collagen fibers. Influence of fibrillar alignment and decorin on mechanical properties. Biophysical Journal. 1997;73:2164–2172
  27. Puustjarvi K, Nieminen J, Rasanen T, Hyttinen M, Helminen HJ, Kroger H, et al. Do more highly organized collagen fibrils increase bone mechanical strength in loss of mineral density after one-year running training?. Journal of Bone and Mineral Research. 1999;14:321–329
  28. Sasaki N, Odajima S. Elongation mechanism of collagen and force–strain relations of tendon at each level of structural hierarchy. Journal of Biomechanics. 1996;29:1131–1136
  29. Sasaki N, Matsushima N, Ikawa T, Yamamura H, Fukuda A. Orientation of bone mineral and its role in the anisotropic mechanical properties of bone: transverse anisotropy. Journal of Biomechanics. 1989;22:157–164
  30. Sevostianov I, Kachanov M. Impact of the porous microstructure on the overall elastic properties of the osteonal cortical bone. Journal of Biomechanics. 2000;33:881–888
  31. Wang X, Shen X, Li X, Agrawal CM. Age-related changes in the collagen network and toughness of bone. Bone. 2002;31:1–7
  32. Zioupos P, Currey JD, Hamer AJ. The role of collagen in the declining mechanical properties of aging human cortical bone. Journal of Biomedical Materials Research. 1999;45:108–116

PII: S0021-9290(05)00534-8

doi: 10.1016/j.jbiomech.2005.11.016

Journal of Biomechanics
Volume 40, Issue 1 , Pages 36-45 , 2007

Article Tools

* Image Usage & Resolution