Synthesis and characterisation of core–shell structures for orthopaedic surgery

Rusen, Edina; Zaharia, Cătălin; Zecheru, Teodora; Mărculescu, Bogdan; Filmon, Robert; Chappard, Daniel; Bădulescu, Roxana; Cincu, Corneliu

doi:10.1016/j.jbiomech.2007.05.002

« Previous Next »Journal of Biomechanics
Volume 40, Issue 15 , Pages 3349-3353, 2007

Synthesis and characterisation of core–shell structures for orthopaedic surgery

Edina Rusen
- Department of Macromolecular Compounds, University Politehnica of Bucharest, 010072 Bucharest, Romania
Cătălin Zaharia
- Department of Macromolecular Compounds, University Politehnica of Bucharest, 010072 Bucharest, Romania
- Faculty of Medicine, University of Angers, INSERM EMI 0335—LHEA, 49045 Angers Cedex, France
Teodora Zecheru
- Department of Macromolecular Compounds, University Politehnica of Bucharest, 010072 Bucharest, Romania
- Faculty of Medicine, University of Angers, INSERM EMI 0335—LHEA, 49045 Angers Cedex, France
- Corresponding author. Department of Macromolecular Compounds, University Politehnica of Bucharest, 010072 Bucharest, Romania. Tel.: +40214022715; fax: +40214023844.
Bogdan Mărculescu
- Department of Macromolecular Compounds, University Politehnica of Bucharest, 010072 Bucharest, Romania
Robert Filmon
- Faculty of Medicine, University of Angers, INSERM EMI 0335—LHEA, 49045 Angers Cedex, France
Daniel Chappard
- Faculty of Medicine, University of Angers, INSERM EMI 0335—LHEA, 49045 Angers Cedex, France
Roxana Bădulescu
- University Petroleum-Gas of Ploieşti, 100520 Ploieşti, Romania
Corneliu Cincu
- Department of Macromolecular Compounds, University Politehnica of Bucharest, 010072 Bucharest, Romania
- Faculty of Medicine, University of Angers, INSERM EMI 0335—LHEA, 49045 Angers Cedex, France

Accepted 3 May 2007. published online 14 June 2007.

Abstract

This paperwork deals with the obtaining and characterisation of new acrylic cements for bone surgery. The final mixture of cement contains derivatives of methacryloyloxyethyl phosphate, methacrylic acid or 2-acrylamido-2-methyl-1-propane sulphonic acid. The idea of using these monomers is sustained by their ability to form ionic bonds with barium, which is responsible for X-ray reflection and by the biocompatibility of these structures.

The strategy consists in the obtaining of core–shell structures through heterogeneous polymerisation, which are used for final cement's manufacture. The orthopaedic cements were characterised by SEM, EDX, compression resistance and cytotoxicity assays.

Keywords: Bone cement, Radio-opacity, Mechanical properties, Cytotoxicity assays