Journal of Biomechanics
Volume 41, Issue 9 , Pages 1840-1846 , 2008

Rheological properties of the vitreous and the role of hyaluronic acid

  • Charles S. Nickerson

      Affiliations

    • Division of Chemistry and Chemical Engineering, California Institute of Technology, Chemical Engineering 210-41, 1200 E. California Blvd., Pasadena, CA 91125, USA
    • ,
  • John Park

      Affiliations

    • Vitreoretinal Technologies, Inc., Irvine, CA, USA
    • ,
  • Julia A. Kornfield

      Affiliations

    • Division of Chemistry and Chemical Engineering, California Institute of Technology, Chemical Engineering 210-41, 1200 E. California Blvd., Pasadena, CA 91125, USA
    • Corresponding Author InformationCorresponding author. Tel.: +16263954138; fax: +16265688743.
    • ,
  • Hampar Karageozian

      Affiliations

    • Vitreoretinal Technologies, Inc., Irvine, CA, USA

,Accepted 8 April 2008.

References 

  1. Ansari RR, Suh KI, Dunker S, Kitaya N, Sebag J. Quantitative molecular characterization of bovine vitreous and lens with non-invasive dynamic light scattering. Experimental Eye Research. 2001;73:859–866
  2. Bettelheim FA, Wang TJY. Dynamic viscoelastic properties of bovine vitreous. Experimental Eye Research. 1976;23:435–441
  3. Bishop PN. Structural macromolecules and supramolecular organisation of the vitreous gel. Progress in Retinal and Eye Research. 2000;19:323–344
  4. Bos KJ, Holmes DF, Meadows RS, Kadler KE, McLeod D, Bishop PN. Collagen fibril organisation in mammalian vitreous by freeze etch/rotary shadowing electron microscopy. Micron. 2001;32:301–306
  5. Chirila TV, Hong Y, Dalton PD, Constable IJ, Refojo MF. The use of hydrophilic polymers as artificial vitreous. Progress in Polymer Science. 1998;23:475–508
  6. Dalton PD, Chirila TV, Hong Y, Jefferson A. Oscillatory shear experiments as criteria for potential vitreous substitutes. Polymer Gels and Networks. 1995;3:429–444
  7. Ferry JD. Viscoelastic Properties of Polymers. third ed. New York: Wiley; 1980;
  8. Flory PJ. Principles of Polymer Chemistry. Ithaca, NY: Cornell University Press; 1953;
  9. Hasler EM, Herzog W, Wu JZ, Muller W, Wyss U. Articular cartilage biomechanics: theoretical models, material properties, and biosynthetic response. Critical Reviews in Biomedical Engineering. 1999;27:415–488
  10. Lee B, Litt M, Buchsbaum G. Rheology of the vitreous body. Part I: Viscoelasticity of human vitreous. Biorheology. 1992;29:521–533
  11. Lee B, Litt M, Buchsbaum G. Rheology of the vitreous body: Part 2. Viscoelasticity of bovine and porcine vitreous. Biorheology. 1994;31:327–338
  12. Lee B, Litt M, Buchsbaum G. Rheology of the vitreous body: Part 3. Concentration of electrolytes, collagen and hyaluronic acid. Biorheology. 1994;31:339–351
  13. Mendichi R, Soltes L, Schieroni AG. Evaluation of radius of gyration and intrinsic viscosity molar mass dependence and stiffness of hyaluronan. Biomacromolecules. 2003;4:1805–1810
  14. Nickerson CS, Kornfield JA. A “cleat” geometry for suppressing wall slip. Journal of Rheology. 2005;49:865–874
  15. Nickerson CS, Karageozian HL, Park J, Kornfield JA. Internal tension: a novel hypothesis concerning the mechanical properties of the vitreous humor. Macromolecular Symposia. 2005;227:183–189
  16. Pfeiffer HH. Zur analyse der fliess-elastizitaet durch spinnversuche am corpus vitreus. Biorheology. 1963;1:111–117
  17. Scott JE. Structure and function in extracellular matrices depend on interactions between anionic glycosaminoglycans. Pathologie Biologie. 2001;49:284–289
  18. Sebag J. The Vitreous — Structure, Function, and Pathobiology. New York: Springer; 1989;
  19. Sebag J, Balazs E. Morphology and ultrastructure of human vitreous fibers. Investigative Ophthalmology and Visual Science. 1989;30:1867–1871
  20. Soman N, Banerjee R. Artificial vitreous replacements. Bio-Medical Materials and Engineering. 2003;13:59–74
  21. Tokita M, Fujiya Y, Hikichi K. Dynamic viscoelasticity of bovine vitreous body. Biorheology. 1984;21:751–756
  22. Vogel S. Comparative biomechanics: Life's physical world. Princeton, NJ: Princeton University Press; 2003;
  23. Walton KA, Meyer CH, Harkrider CJ, Cox TA, Toth CA. Age-related changes in vitreous mobility as measured by video B scan ultrasound. Experimental Eye Research. 2002;74:173–180
  24. Weber H, Landwehr G, Kilp H, Neubauer H. The mechanical-properties of the vitreous of pig and human donor eyes. Ophthalmic Research. 1982;14:335–343
  25. Zimmerman RL. In vivo measurements of the viscoelasticity of the human vitreous-humor. Biophysical Journal. 1980;29:539–544

PII: S0021-9290(08)00191-7

doi: 10.1016/j.jbiomech.2008.04.015

Journal of Biomechanics
Volume 41, Issue 9 , Pages 1840-1846 , 2008

Article Tools

* Image Usage & Resolution