Permeability evaluation of 45S5 Bioglass®-based scaffolds for bone tissue engineering

Ochoa, Ignacio; Sanz-Herrera, José A.; García-Aznar, José M.; Doblaré, Manuel; Yunos, Darmawati Mohamad; Boccaccini, Aldo R.

doi:10.1016/j.jbiomech.2008.10.030

« Previous Next »Journal of Biomechanics
Volume 42, Issue 3 , Pages 257-260, 9 February 2009

Permeability evaluation of 45S5 Bioglass^®-based scaffolds for bone tissue engineering

Ignacio Ochoa
- Aragon Institute of Engineering Research (I3A), Group of Structural Mechanics and Materials Modelling (GEMM), Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Universidad de Zaragoza, 50018 Zaragoza, Spain
José A. Sanz-Herrera
- Aragon Institute of Engineering Research (I3A), Group of Structural Mechanics and Materials Modelling (GEMM), Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Universidad de Zaragoza, 50018 Zaragoza, Spain
José M. García-Aznar
- Aragon Institute of Engineering Research (I3A), Group of Structural Mechanics and Materials Modelling (GEMM), Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Universidad de Zaragoza, 50018 Zaragoza, Spain
Manuel Doblaré
- Aragon Institute of Engineering Research (I3A), Group of Structural Mechanics and Materials Modelling (GEMM), Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Universidad de Zaragoza, 50018 Zaragoza, Spain
Darmawati Mohamad Yunos
- Department of Materials, Imperial College London, South Kensington Campus, London SW7 2BP, UK
Aldo R. Boccaccini
- Department of Materials, Imperial College London, South Kensington Campus, London SW7 2BP, UK
- Corresponding author. Tel.: +442075946731.

Accepted 29 October 2008. published online 23 December 2008.

Abstract

Permeability is a key parameter for microstructural design of scaffolds, since it is related to their capability for waste removal and nutrients/oxygen supply. In this framework, Darcy's experiments were carried out in order to determine the relationship between the pressure drop gradient and the fluid flow velocity in Bioglass^®-based scaffolds to obtain the scaffold's permeability. Using deionised water as working fluid, the measured average permeability value on scaffolds of 90–95% porosity was 1.96×10⁻⁹m². This value lies in the published range of permeability values for trabecular bone.

Keywords: Bioglass^® scaffolds, Permeability, Darcy's equation, Tissue engineering