Repeated application of incremental landing impact loads to intact knee joints induces anterior cruciate ligament failure and tibiofemoral cartilage deformation and damage: A preliminary cadaveric investigation

Yeow, C.H.; Ng, K.S.; Cheong, C.H.; Lee, P.V.S.; Goh, J.C.H.

doi:10.1016/j.jbiomech.2009.03.026

« Previous Next »Journal of Biomechanics
Volume 42, Issue 8 , Pages 972-981, 29 May 2009

Repeated application of incremental landing impact loads to intact knee joints induces anterior cruciate ligament failure and tibiofemoral cartilage deformation and damage: A preliminary cadaveric investigation

C.H. Yeow
- Department of Orthopaedic Surgery, National University of Singapore, Singapore
- Division of Bioengineering, National University of Singapore, Singapore
K.S. Ng
- Division of Bioengineering, National University of Singapore, Singapore
C.H. Cheong
- Biomechanics Lab, Defence Medical and Environmental Research Institute, Singapore
P.V.S. Lee
- Division of Bioengineering, National University of Singapore, Singapore
- Biomechanics Lab, Defence Medical and Environmental Research Institute, Singapore
- Department of Mechanical Engineering, University of Melbourne, Australia
J.C.H. Goh
- Department of Orthopaedic Surgery, National University of Singapore, Singapore
- Division of Bioengineering, National University of Singapore, Singapore
- Corresponding author at: Department of Orthopaedic Surgery, NUS Tissue Engineering Program, Office of Life Sciences, National University of Singapore, 27 Medical Drive, Singapore 117510. Tel.: +06565165259; fax: +06567765322.

Accepted 2 March 2009. published online 20 April 2009.

Abstract

Anterior cruciate ligament (ACL) injury is a major problem worldwide and prevails during high-impact activities. It is not well-understood how the extent and distribution of cartilage damage will arise from repetitive landing impact loads that can lead to ACL failure. This study seeks to investigate the sole effect of repetitive incremental landing impact loads on the induction of ACL failure, and extent and distribution of tibiofemoral cartilage damage in cadaveric knees. Five cadaveric knees were mounted onto a material testing system at 70° flexion to simulate landing posture. A motion-capture system was used to track rotational and translational motions of the tibia and femur, respectively. Each specimen was compressed at a single 10Hz haversine to simulate landing impact. The compression trial was successively repeated with increasing actuator displacement till a significant compressive force drop was observed. All specimens underwent ACL failure, which was confirmed via magnetic resonance scans and dissection. Volume analysis, thickness measurement and histological techniques were employed to assess cartilage lesion status. For each specimen, the highest peak compressive force (1.9–7.8kN) was at the final trial in which ACL failure occurred; corresponding posterior femoral displacement (7.6–18.0mm) and internal tibial rotation (0.6°–4.7°) were observed. Significant compressive force drop (79.8–90.9%) was noted upon ACL failure. Considerable cartilage deformation and damage were found in exterior, posterior and interior femoral regions with substantial volume reduction in lateral compartments. Repeated application of incremental landing impact loads can induce both ACL failure and cartilage damage, which may accelerate the risk of developing osteoarthritis.

Keywords: Knee joint, Anterior cruciate ligament, Cartilage damage, Failure mechanism, Landing impact load