Journal of Biomechanics
Volume 42, Issue 11 , Pages 1692-1696 , 7 August 2009

Biaxial cell stimulation: A mechanical validation

  • F.H. Bieler

      Affiliations

    • Julius Wolff Institut and Center for Musculoskeletal Surgery, Berlin/Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany
    • ,
  • C.E. Ott

      Affiliations

    • Institute for Medical Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany
    • ,
  • M.S. Thompson

      Affiliations

    • Department of Engineering Science, University of Oxford, Oxford, United Kingdom
    • ,
  • R. Seidel

      Affiliations

    • Julius Wolff Institut and Center for Musculoskeletal Surgery, Berlin/Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany
    • ,
  • S. Ahrens

      Affiliations

    • Institute for Medical Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany
    • ,
  • D.R. Epari

      Affiliations

    • Julius Wolff Institut and Center for Musculoskeletal Surgery, Berlin/Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany
    • ,
  • U. Wilkening

      Affiliations

    • Max-Planck-Institute for Molecular Genetics, Berlin, Germany
    • ,
  • K.D. Schaser

      Affiliations

    • Julius Wolff Institut and Center for Musculoskeletal Surgery, Berlin/Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany
    • ,
  • S. Mundlos

      Affiliations

    • Institute for Medical Genetics, Charité – Universitätsmedizin Berlin, Berlin, Germany
    • Max-Planck-Institute for Molecular Genetics, Berlin, Germany
    • ,
  • G.N. Duda

      Affiliations

    • Julius Wolff Institut and Center for Musculoskeletal Surgery, Berlin/Brandenburg Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, 13353 Berlin, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +4930450559079; fax: +4930450559969.

,Accepted 15 April 2009.

References 

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  5. Grabner B, Varga F, Fratzl-Zelman N, Luegmayr E, Glantschnig H, Rumpler M, et al. A new stretching apparatus for applying anisotropic mechanical strain to bone cells in-vitro. Review of Scientific Instruments. 2000;71:3522–3529
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  13. Thompson MS, Schell H, Lienau J, Duda GN. Digital image correlation: a technique for determining local mechanical conditions within early bone callus. Medical Engineering and Physics. 2007;29:820–823
  14. Trepat X, Deng L, An SS, Navajas D, Tschumperlin DJ, Gerthoffer WT, et al. Universal physical responses to stretch in the living cell. Nature. 2007;447:592–595
  15. Vande Geest JP, Di Martino ES, Vorp DA. An analysis of the complete strain field within Flexercell membranes. Journal of Biomechanics. 2004;37:1923–1928
  16. Wall ME, Weinhold PS, Siu T, Brown TD, Banes AJ. Comparison of cellular strain with applied substrate strain in vitro. Journal of Biomechanics. 2007;40:173–181
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PII: S0021-9290(09)00215-2

doi: 10.1016/j.jbiomech.2009.04.013

Journal of Biomechanics
Volume 42, Issue 11 , Pages 1692-1696 , 7 August 2009

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