Journal of Biomechanics
Volume 43, Issue 1 , Pages 31-37 , 5 January 2010

The mechanochemistry of integrated motor protein complexes

  • Pamela E. Constantinou

      Affiliations

    • Department of Bioengineering, Rice University, 6100 Main Street, MS-142, Houston, TX77005 USA
    • ,
  • Michael R. Diehl

      Affiliations

    • Department of Bioengineering, Rice University, 6100 Main Street, MS-142, Houston, TX77005 USA
    • Department of Chemistry, Rice University, 6100 Main Street, MS-142, Houston, TX77005 USA
    • Corresponding Author InformationCorresponding author at: Department of Bioengineering, Rice University, 6100 Main Street, MS-142, Houston, TX77005 USA. Tel.: +7133484568; fax: +7133485877.

,Accepted 21 August 2009.

References 

  1. Asbury CL, Fehr AN, Block SM. Kinesin moves by an asymmetric hand-over-hand mechanism. Science. 2003;302:2130–2134
  2. Bieling P, Telley IA, Piehler J, Surrey T. Processive kinesins require loose mechanical coupling for efficient collective motility. European Molecular Biology Organization Reports. 2008;9:1121–1127
  3. Carter NJ, Cross RA. Mechanics of the kinesin step. Nature. 2005;435:308–312
  4. Diehl MR, Zhang K, Lee HJ, Tirrell DA. Engineering cooperativity in biomotor-protein assemblies. Science. 2006;311:1468–1471
  5. Endow SA, Higuchi H. A mutant of the motor protein kinesin that moves in both directions on microtubules. Nature. 2000;406:913–916
  6. Gennerich A, Schild D. Finite-particle tracking reveals submicroscopic-size changes of mitochondria during transport in mitral cell dendrites. Physical Biology. 2006;3:45–53
  7. Gennerich A, Carter AP, Reck-Peterson SL, Vale RD. Force-induced bidirectional stepping of cytoplasmic dynein. Cell. 2007;131:952–965
  8. Gennerich A, Vale RD. Walking the walk: how kinesin and dynein coordinate their steps. Current Opinion in Cell Biology. 2009;21:59–67
  9. Goldstein LSB. Kinesin molecular motors: transport pathways, receptors, and human diseases. Proceedings of the National Academy of Sciences. 2001;98:6999–7003
  10. Gross SP, Tuma MC, Deacon SW, Serpinskaya AS, Reilein AR, Gelfand VI. Interactions and regulation of molecular motors in Xenopus melanophores. Journal of Cell Biology. 2002;156:855–865
  11. Hill D, Plaza M, Bonin K, Holzwarth G. Fast vesicle transport in PC12 neurites: velocities and forces. European Biophysics Journal. 2004;33:623–632
  12. Hirokawa N, Pfister KK, Yorifuji H, Wagner MC, Brady ST, Bloom GS. Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration. Cell. 1989;56:867–878
  13. Holzbaur ELF. Motor neurons rely on motor proteins. Trends in Cell Biology. 2004;14:233–240
  14. Howard J. Mechanics of Motor Proteins and the Cytoskeleton. Sunderland, MA: Sinauer Associates; 2001;
  15. Karki S, Holzbaur ELF. Cytoplasmic dynein and dynactin cell division and intracellular transport. Current Opinion in Cell Biology. 1999;11:45–53
  16. King SJ, Schroer TA. Dynactin increases the processivity of the cytoplasmic dynein complex. Nature Cell Biology. 2000;2:20–24
  17. King SJ, Bonilla M, Rodgers ME, Schroer TA. Subunit organization in cytoplasmic dynein subcomplexes. Protein Science. 2002;11:1239–1250
  18. Klumpp S, Lipowsky R. Cooperative cargo transport by several molecular motors. Proceedings of the National Academy of Sciences. 2005;102:17284–17289
  19. Kojima H, Muto E, Higuchi H, Yanagida T. Mechanics of single kinesin molecules measured by optical trapping nanometry. Biophysical Journal. 1997;73:2012–2022
  20. Kulic IM, Brown AEX, Kim H, Kural C, Blehm B, Selvin PR, et al. The role of microtubule movement in bidirectional organelle transport. Proceedings of the National Academy of Sciences. 2008;105:10011–10016
  21. Kural C, Kim H, Syed S, Goshima G, Gelfand VI, Selvin PR. Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement?. Science. 2005;308:1469–1472
  22. Laib JA, Marin JA, Bloodgood RA, Guilford WH. The reciprocal coordination and mechanics of molecular motors in living cells. Proceedings of the National Academy of Sciences. 2009;106:3190–3195
  23. Leduc C, Campas O, Zeldovich KB, Roux A, Jolimaitre P, Bourel-Bonnet L, et al. Cooperative extraction of membrane nanotubes by molecular motors. Proceedings of the National Academy of Sciences. 2004;101:17096–17101
  24. Leduc C, Ruhnow F, Howard J, Diez S. Detection of fractional steps in cargo movement by the collective operation of kinesin-1 motors. Proceedings of the National Academy of Sciences. 2007;104:10847–10852
  25. Mesngon MT, Tarricone C, Hebbar S, Guillotte AM, Schmitt EW, Lanier L, et al. Regulation of cytoplasmic dynein ATPase by Lis1. The Journal of Neuroscience. 2006;26:2132–2139
  26. Moore JK, Sept D, Cooper JA. Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration. Proceedings of the National Academy of Sciences. 2009;106:5147–5152
  27. Nan X, Sims PA, Xie XS. Organelle tracking in a living cell with microsecond time resolution and nanometer spatial precision. Chem. Phys. Chem. 2008;9:707–712
  28. Pfister KK, Salata MW, Dillman 3rd. JF, Torre E, Lye RJ. Identification and developmental regulation of a neuron-specific subunit of cytoplasmic dynein. Molecular Biology of the Cell. 1996;7:331–343
  29. Pfister KK, Shah PR, Hummerich H, Russ A, Cotton J, Annuar AA, et al. Genetic analysis of the cytoplasmic dynein subunit families. Public Library of Science Genetics. 2006;2:11–26
  30. Rogers AR, Driver DW, Constantinou PE, Jamison DK, Diehl MR. Negative cooperativity dominates collective transport of kinesin motors in the absence of load. Physical Chemistry Chemical Physics. 2009;11:4882–4889
  31. Ross JL, Wallace K, Shuman H, Goldman YE, Holzbaur ELF. Processive bidirectional motion of dynein–dynactin complexes in vitro. Nature Cell Biology. 2006;8:562–570
  32. Ross JL, Shuman H, Holzbaur ELF, Goldman YE. Kinesin and dynein–dynactin at intersecting microtubules: Motor density affects dynein function. Biophysical Journal. 2008;94:3115–3125
  33. Selvin PR, Ha T. Single-Molecule Techniques: A Laboratory Manual. Woodbury, NY: Cold Spring Harbor Laboratory Press; 2008;
  34. Schwaiger I, Sattler C, Hostetter DR, Rief M. The myosin coiled-coil is a truly elastic protein structure. Nature Materials. 2002;1:232–235
  35. Schweller RM, Constantinou PE, Frankel NW, Narayan P, Diehl MR. Design of DNA-conjugated polypeptide-based capture probes for the anchoring of proteins to DNA matrices. Bioconjugate Chemistry. 2008;19:2304–2307
  36. Vale RD, Funatsu T, Pierce DW, Romberg L, Harada Y, Yanagida T. Direct observation of single kinesin molecules moving along microtubules. Nature. 1996;380:451–453
  37. Vershinin M, Carter BC, Razafsky DS, King SJ, Gross SP. Multiple motor based transport and its regulation by Tau. Proceedings of the National Academy of Sciences. 2007;104:87–92
  38. Visscher K, Schnitzer MJ, Block SM. Single kinesin molecules studied with a molecular force clamp. Nature. 1999;400:184–189
  39. Wynshaw-Boris A, Gambello MJ. LIS1 and dynein motor function in neuronal migration and development. Genes and Development. 2001;15:639–651
  40. Yildiz A, Tomishige M, Vale RD, Selvin PR. Kinesin walks hand-over hand. Science. 2004;303:676–678
  41. Yildiz A, Tomishige M, Gennerich A, Vale RD. Intramolecular strain coordinates kinesin stepping behavior along microtubules. Cell. 2008;134:1030–1041
  42. Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan J, et al. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Molecular Biology of the Cell. 2005;16:3187–3199

PII: S0021-9290(09)00497-7

doi: 10.1016/j.jbiomech.2009.09.006

Journal of Biomechanics
Volume 43, Issue 1 , Pages 31-37 , 5 January 2010

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