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Journal of Biomechanics
Volume 43, Issue 1
, Pages 38-44
, 5 January 2010
The biomechanical integrin
References
- Molecular Biology of the Cell. Garland Science. New York: Taylor & Francis Group; 2008;
- Structure and mechanics of integrin-based cell adhesion. Current Opinion in Cell Biology. 2007;19:495–507
- . Anchorage-dependent cell cycle progression. Journal of Cell Biology. 1997;136:1–4
- Extracellular matrix stiffness and architecture govern intracellular rheology in cancer. Biophysical Journal. 2009;97:1013–1021
- Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nature Cell Biology. 2001;3:466–472
- Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior. Journal of Cell Biology. 2001;155:1319–1332
- . A model for shear stress-induced deformation of a flow sensor on the surface of vascular endothelial cells. Journal of Theoretical Biology. 2001;210:221–236
- Local measurements of viscoelastic parameters of adherent cell surfaces by magnetic bead microrheometry. Biophysical Journal. 1998;75:2038–2049
- Cell-adhesion-competition between nonspecific repulsion and specific bonding. Biophysical Journal. 1984;45:1051–1064
- Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. Journal of Cell Biology. 2001;153:881–887
- . Measuring cell adhesion forces with the atomic force microscope at the molecular level. Karger. 2002;174–189
- . Integrins as targets in therapy. Expert Opinion on Therapeutic Patents. 2006;16:963–975
- Cytoskeletal remodelling and slow dynamics in the living cell. Nature Materials. 2005;4:557–561
- Keratocytes generate traction forces in two phases. Molecular Biology of the Cell. 1999;10:3745–3769
- . Traction forces of cytokinesis measured with optically modified elastic substrata. Nature. 1997;385:450–454
- Traction fields, moments, and strain energy that cells exert on their surroundings. American Journal of Physiology—Cell Physiology. 2002;282:C595–C605
- Rab25 associates with alpha 5 beta 1 integrin to promote invasive migration in 3D microenvironments. Developmental Cell. 2007;13:496–510
- Integrin-mediated cell-adhesion activates mitogen-activated protein-kinases. Journal of Biological Chemistry. 1994;269:26602–26605
- . Mechanotransduction—a field pulling together?. Journal of Cell Science. 2008;121:3285–3292
- Molecular basis of mechanical modulation of endothelial cell migration. Frontiers in Bioscience. 2005;10:1985–2000
- . Integrins and signal-transduction pathways—the road taken. Science. 1995;268:233–239
- . Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophysical Journal. 1999;76:2307–2316
- Fast and slow dynamics of the cytoskeleton. Nature Materials. 2006;5:636–640
- A model for the contractility of the cytoskeleton including the effects of stress-fibre formation and dissociation. Proceedings of the Royal Society a—Mathematical Physical and Engineering Sciences. 2007;463:787–815
- A bio-mechanical model for coupling cell contractility with focal adhesion formation. Journal of the Mechanics and Physics of Solids. 2008;56:1484–1510
- Tissue cells feel and respond to the stiffness of their substrate. Science. 2005;310:1139–1143
- . Remote control of cellular behaviour with magnetic nanoparticles. Nature Nanotechnology. 2008;3:139–143
- Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system. Journal of Cellular and Molecular Medicine. 2007;11:21–38
- . The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cells. Journal of Biological Chemistry. 1996;271:2443–2447
- Force mapping in epithelial cell migration. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:2390–2395
- . Dynamic strength of molecular adhesion bonds. Biophysical Journal. 1997;72:1541–1555
- . Function and interactions of integrins. Cell and Tissue Research. 2001;305:285–298
- Recent advances into the understanding of mesenchymal stem cell trafficking. British Journal of Haematology. 2007;137:491–502
- Force required to break alpha(5)beta(1) integrin–fibronectin bonds in intact adherent cells is sensitive to integrin activation state. Journal of Biological Chemistry. 1998;273:10988–10993
- Transmembrane extracellular matrix—cytoskeleton crosstalk. Nature Reviews Molecular Cell Biology. 2001;2:793–805
- Localized alpha 4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circulation Research. 2008;103:177–185
- . Integrin signalling during tumour progression. Nature Reviews Molecular Cell Biology. 2004;5:816–826
- . Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells. Cardiovascular Research. 2006;72:375–383
- . The hallmarks of cancer. Cell. 2000;100:57–70
- Microarchitecture of three-dimensional scaffolds influences cell migration behavior via junction interactions. Biophysical Journal. 2008;95:4013–4024
- Silicone-rubber substrata—new wrinkle in the study of cell locomotion. Science. 1980;208:177–179
- . Integrins: Bidirectional, allosteric signaling machines. Cell. 2002;110:673–687
- . A reevaluation of integrins as regulators of angiogenesis. Nature Medicine. 2002;8:918–921
- . The emergence of integrins: a personal and historical perspective. Matrix Biology. 2004;23:333–340
- . Cell–matrix Adhesion in Vascular Development. Blackwell Publishing; 2007;p. 32–40
- . Mechanical signalling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. Circulation Research. 2002;91:877–887
- . Tensegrity I. Cell structure and hierarchical systems biology. Journal of Cell Science. 2003;116:1157–1173
- . Cellular mechanotransduction: putting all the pieces together again. Faseb Journal. 2006;20:811–827
- . Rho GTPases: biochemistry and biology. Annual Review of Cell and Developmental Biology. 2005;21:247–269
- Epidermal stem cells. Journal of Pathology. 2002;197:479–491
- Structure and assembly of hemidesmosomes. Bioessays. 1998;20:488–494
- . Using model substrates to study the dependence of focal adhesion formation on the affinity of integrin–ligand complexes. Biochemistry. 2004;43:2699–2707
- . Integrins in morphogenesis and signaling. Biochimie. 1997;79:467–476
- . Intercellular mechanotransduction: cellular circuits that coordinate tissue responses to mechanical loading. Biochemical and Biophysical Research Communications. 2001;285:1077–1083
- Collective and single-molecule interactions of alpha(5)beta(1) integrins. Langmuir. 2004;20:2397–2404
- . Cell migration: a physically integrated molecular process. Cell. 1996;84:359–369
- Traction forces generated by locomoting keratocytes. Journal of Cell Biology. 1994;127:1957–1964
- Force measurements of the alpha(5)beta(1) integrin–fibronectin interaction. Biophysical Journal. 2003;84:1252–1262
- . Mechanical stress-initiated signal transductions in vascular smooth muscle cells. Cellular Signalling. 2000;12:435–445
- Cell movement is guided by the rigidity of the substrate. Biophysical Journal. 2000;79:144–152
- Cell–matrix adhesion complexes: master control machinery of cell migration. Seminars in Cancer Biology. 2008;18:65–76
- The coupling of alpha(6)beta(4) integrin to Ras–MAP kinase pathways mediated by Shc controls keratinocyte proliferation. Embo Journal. 1997;16:2365–2375
- Demonstration of mechanical connections between integrins cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proceedings of the National Academy of Sciences of the United States of America. 1997;94:849–854
- Energy landscapes of receptor–ligand bonds explored with dynamic force spectroscopy. Nature. 1999;397:50–53
- Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Seminars in Cell & Developmental Biology. 2008;19:215–223
- . Rheology of the Cytoskeleton. Annual Review of Fluid Mechanics. 2009;41:433–453
- . Limitation of cell adhesion by the elasticity of the extracellular matrix. Biophysical Journal. 2006;91:61–73
- Integrin beta 4 signaling promotes tumor angiogenesis. Cancer Cell. 2004;6:471–483
- Integrin dynamics on the tail region of migrating fibroblasts. Journal of Cell Science. 1996;109(Pt 5):941–952
- Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. Journal of Cell Biology. 2000;148:1075–1090
- Molecular pathways in bone marrow homing: dominant role of alpha 4 beta 1 over beta 2-integrins and selectins. Blood. 2001;98:2403–2411
- Tensional homeostasis and the malignant phenotype. Cancer Cell. 2005;8:241–254
- . The tension mounts: mechanics meets morphogenesis and malignancy. Journal of Mammary Gland Biology and Neoplasia. 2004;9:325–342
- Propagation of mechanical stress through the actin cytoskeleton toward focal adhesions: model and experiment. Biophysical Journal. 2008;94:1470–1482
- . Cell locomotion and focal adhesions are regulated by substrate flexibility. Proceedings of the National Academy of Sciences of the United States of America. 1997;94:13661–13665
- . Focal adhesions: structure and dynamics. Biology of the Cell. 2000;92:477–494
- . Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion. Journal of Cellular Physiology. 2005;204:198–209
- Ligand binding to integrins. Journal of Biological Chemistry. 2000;275:21785–21788
- . The mechanical integrin cycle. Journal of Cell Science. 2009;122:179–186
- Part II: fibroblasts preferentially migrate in the direction of principal strain. Biomechanics and Modeling in Mechanobiology. 2008;7:215–225
- Endothelial cell traction forces on RGD-derivatized polyacrylamide substrata. Langmuir. 2003;19:1573–1579
- Cell migration: integrating signals from front to back. Science. 2003;302:1704–1709
- Stretching single Talin rod molecules activates Vinculin binding. Science. 2009;323:638–641
- Stimulation of lung carcinoma cell growth by fibronectin–integrin signalling. Molecular Biosystems. 2008;4:1160–1169
- Slow stress propagation in adherent cells. Biophysical Journal. 2008;95:6052–6059
- . Integrins and the myocardium. Circulation Research. 2001;88:1112–1119
- alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. Journal of Cell Science. 2003;116:3543–3556
- The viscoelasticity of membrane tethers and its importance for cell adhesion. Biophysical Journal. 2008;95:1448–1459
- . Networks and crosstalk: integrin signalling spreads. Nature Cell Biology. 2002;4:E65–E68
- . Integrating with integrins. Molecular Biology of the Cell. 1994;5:389–393
- Integrins and angiogenesis: a sticky business. Experimental Cell Research. 2006;312:651–658
- . Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood. 2004;104:1606–1615
- . A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397. Molecular Biology of the Cell. 2003;14:4306–4315
- . Patterns of cell motility in the organizer and dorsal mesoderm of Xenopus-Laevis. Development. 1992;116:915–916
- . Role of integrins in cellular responses to mechanical stress and adhesion. Current Opinion in Cell Biology. 1997;9:707–713
- Cell–matrix, and cell–cell interactions during corneal epithelial wound healing. Progress in Retinal and Eye Research. 2003;22:113–133
- Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell. 1986;46:271–282
- Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proceedings of the National Academy of Sciences of the United States of America. 2003;100:1484–1489
- Myofibroblasts and mechano-regulation of connective tissue remodelling. Nature Reviews Molecular Cell Biology. 2002;3:349–363
- Adhesion molecules involved in transendothelial migration of human hematopoietic progenitor cells. Stem Cells. 2000;18:435–443
- . Local force and geometry sensing regulate cell functions. Nature Reviews Molecular Cell Biology. 2006;7:265–275
- alpha(4)beta(1) integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction. Circulation Research. 2002;90:473–480
- Mechanotransduction across the cell-surface and through the cytoskeleton. Science. 1993;260:1124–1127
- Substrate flexibility regulates growth and apoptosis of normal but not transformed cells. American Journal of Physiology—Cell Physiology. 2000;279:C1345–C1350
- Mechanical behavior in living cells consistent with the tensegrity model. Proceedings of the National Academy of Sciences of the United States of America. 2001;98:7765–7770
- Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells. American Journal of Physiology—Cell Physiology. 2002;282:C606–C616
- Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nature Reviews Molecular Cell Biology. 2009;10:75–82
- . Cell traction force and measurement methods. Biomechanics and Modeling in Mechanobiology. 2007;6:361–371
- . An introductory review of cell mechanobiology. Biomechanics and Modeling in Mechanobiology. 2006;5:1–16
- beta 4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002;2:205–216
- Structural basis of integrin activation by talin. Cell. 2007;128:171–182
- . Integrin-dependent pathologies. Journal of Pathology. 2003;200:481–487
- Targeted disruption of beta 1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell. 2004;6:159–170
- WHO, Cancer Fact Sheet no. 297. World Health Organization, 2009.
- Integrin–actin interactions. Cmls—Cellular and Molecular Life Sciences. 2005;62:1081–1099
- Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. Journal of Cell Biology. 2003;160:267–277
- . Adhesion dynamics: mechanisms and measurements. International Journal of Biochemistry & Cell Biology. 2008;40:2397–2409
- Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature. 2004;432:59–67
- . Integrin transmembrane signaling and cytoskeletal control. Current Opinion in Cell Biology. 1995;7:681–689
- Determining substrate displacement and cell traction fields—a new approach. Journal of Theoretical Biology. 2006;242:607–616
- . Free energy landscape of receptor mediated cell adhesion. Journal of Chemical Physics. 2007;126:045103
- . Regulation of cell adhesion free energy by external sliding velocities. Experimental Mechanics. 2009;49:57–63
- . Cell adhesion to nanoligands: effects of ligand size and concentration in solution. Langmuir. 2008;24:11819–11827
- . Thermodynamics of clustered and unclustered receptor systems in cell adhesion. Chem. Phys. Lett. 2008;452:362–366
- Autocrine laminin-5 ligates alpha 6 beta 4 integrin and activates RAC and NF kappa B to mediate anchorage-independent survival of mammary tumors. Journal of Cell Biology. 2003;163:1397–1407
- Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. Journal of Cell Science. 2003;116:4605–4613
- Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell–matrix adhesion and proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 2006;103:10889–10894
- How focal adhesion size depends on integrin affinity. Langmuir. 2009;25:1540–1546
PII: S0021-9290(09)00498-9
doi: 10.1016/j.jbiomech.2009.09.007
© 2009 Elsevier Ltd. All rights reserved.
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Journal of Biomechanics
Volume 43, Issue 1
, Pages 38-44
, 5 January 2010
