Journal of Biomechanics
Volume 43, Issue 9 , Pages 1696-1701 , 18 June 2010

Biaxial mechanical testing of human sclera

  • Armin Eilaghi

      Affiliations

    • Department of Mechanical and Industrial Engineering, University of Toronto, Canada
    • Institute for Biomaterials and Biomedical Engineering, University of Toronto, Canada
    • ,
  • John G. Flanagan

      Affiliations

    • Department of Ophthalmology and Vision Sciences, University of Toronto, Canada
    • Optometry School, University of Waterloo, Canada
    • ,
  • Inka Tertinegg

      Affiliations

    • Department of Ophthalmology and Vision Sciences, University of Toronto, Canada
    • ,
  • Craig A. Simmons

      Affiliations

    • Department of Mechanical and Industrial Engineering, University of Toronto, Canada
    • Institute for Biomaterials and Biomedical Engineering, University of Toronto, Canada
    • ,
  • G. Wayne Brodland

      Affiliations

    • Department of Civil and Environmental Engineering, University of Waterloo, Canada
    • Department of Biology, University of Waterloo, Canada
    • ,
  • C. Ross Ethier

      Affiliations

    • Department of Mechanical and Industrial Engineering, University of Toronto, Canada
    • Institute for Biomaterials and Biomedical Engineering, University of Toronto, Canada
    • Department of Ophthalmology and Vision Sciences, University of Toronto, Canada
    • Department of Bioengineering, Imperial College London, UK
    • Corresponding Author InformationCorresponding author at: Department of Bioengineering, Imperial College, London SW7 2AZ, UK. Tel.: +4402075949795; fax: +4402075949787.

,Accepted 24 February 2010.

References 

  1. Allingham RR, Shields MB. Shields’ Textbook of Glaucoma. Philadelphia: Lippincott Williams & Wilkins; 2005;
  2. Battaglioli JL, Kamm RD. Measurements of the compressive properties of scleral tissue. Investigative Ophthalmology and Visual Science. 1984;1:59–65
  3. Bellezza AJ, Hart RT, Burgoyne CF. The optic nerve head as a biomechanical structure: initial finite element modeling. Investigative Ophthalmology and Visual Science. 2000;10:2991–3000
  4. Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Progress in Retinal and Eye Research. 2005;1:39–73
  5. David G, Pedrigi RM, Heistand MR, Humphrey JD. Regional multiaxial mechanical properties of the porcine anterior lens capsule. Journal of Biomechanical Engineering. 2007;1:97–104
  6. Downs JC, Roberts MD, Burgoyne CF. Mechanical environment of the optic nerve head in glaucoma. Optometry and Vision Science. 2008;6:425–435
  7. Downs JC, Suh JK, Thomas KA, Bellezza AJ, Burgoyne CF, Hart RT. Viscoelastic characterization of peripapillary sclera: material properties by quadrant in rabbit and monkey eyes. Journal of Biomechanical Engineering. 2003;1:124–131
  8. Drance SM. Optic Nerve in Glaucoma. New York: Kugler Publications; 1995;
  9. Eilaghi, A., Flanagan. J.G., Brodland, G.W., Ethier, C.R., 2009. Strain uniformity in biaxial specimens is highly sensitive to attachment details. ASME Journal of Biomechanical Engineering 131(9), 091003-1–091003-7
  10. Ethier CR. Scleral biomechanics and glaucoma—a connection?. Canadian Journal of Ophthalmology. 2006;1:9–14
  11. Friberg TR, Lace JW. A comparison of the elastic properties of human choroid and sclera. Experimental Eye Research. 1988;3:429–436
  12. Fung YC. Biomechanics: Mechanical Properties of Living Tissues. New York: Springer-Verlag; 1993;
  13. Girard M, Suh JK, Hart RT, Burgoyne CF, Downs JC. Effects of storage time on the mechanical properties of rabbit peripapillary sclera after enucleation. Current Eye Research. 2007;5:465–470
  14. Hayreh SS. Anterior Ischemic Optic Neuropathy. Berlin: Springer-Verlag; 1975;
  15. Holzapfel GA, Gasser TC, Ogden RW. A new constitutive framework for arterial wall mechanics and a comparative study of material models. Journal of Elasticity. 2000;1–3:1–48
  16. Humphrey JD. An evaluation of pseudoelastic descriptors used in arterial mechanics. Journal of Biomechanical Engineering. 1999;2:259–262
  17. Humphrey JD, Vawter DL, Vito RP. Quantification of strains in biaxially tested soft tissues. Journal of Biomechanics. 1987;1:59–65
  18. Humphrey JD. Cardiovascular Solid Mechanics: Cells, Tissues, and Organs. New York: Springer; 2002;
  19. Kobayashi AS, Woo SL, Lawrence C, Schlegel WA. Analysis of the corneo-scleral shell by the method of direct stiffness. Journal of Biomechanics. 1971;5:323–330
  20. Komai Y, Ushiki T. The three-dimensional organization of collagen fibrils in the human cornea and sclera. Investigative Ophthalmology and Visual Science. 1991;8:2244–2258
  21. Minckler DS. Histology of optic nerve damage in ocular hypertension and early glaucoma. Survey of Ophthalmolody. 1989;(Suppl. April):401–402
  22. Pinsky PM, Van Der Heide D, Chernyak D. Computational modeling of mechanical anisotropy in the cornea and sclera. Journal of Cataract and Refractive Surgery. 2005;1:136–145
  23. Schultz DS, Lotz JC, Lee SM, Trinidad ML, Stewart JM. Structural factors that mediate scleral stiffness. Investigative Ophthalmology and Visual Science. 2008;10:4232–4236
  24. Sigal IA, Flanagan JG, Ethier CR. Factors influencing optic nerve head biomechanics. Investigative Ophthalmology and Visual Science. 2005;11:4189–4199
  25. Sigal IA, Flanagan JG, Tertinegg I, Ethier CR. Finite element modeling of optic nerve head biomechanics. Investigative Ophthalmology and Visual Science. 2004;12:4378–4387
  26. Spoerl E, Boehm AG, Pillunat LE. The influence of various substances on the biomechanical behavior of lamina cribrosa and peripapillary sclera. Investigative Ophthalmology and Visual Science. 2005;4:1286–1290
  27. Summers Rada JA, Shelton S, Norton TT. The sclera and myopia. Experimental Eye Research. 2006;2:185–200
  28. Thale A, Tillmann B. The collagen architecture of the sclera—SEM and immunohistochemical studies. Annals of Anatomy. 1993;3:215–220
  29. Thale A, Tillmann B, Rochels R. Scanning electron-microscopic studies of the collagen architecture of the human sclera—normal and pathological findings. Ophthalmologica. 1996;3:137–141
  30. Watson PG, Young RD. Scleral structure, organisation and disease. A review. Experimental Eye Research. 2004;3:609–623
  31. Wollensak G, Spoerl E. Collagen crosslinking of human and porcine sclera. Journal of Cataract and Refractive Surgery. 2004;3:689–695
  32. Woo SL, Kobayashi AS, Schlegel WA, Lawrence C. Nonlinear material properties of intact cornea and sclera. Experimental Eye Research. 1972;1:29–39

PII: S0021-9290(10)00139-9

doi: 10.1016/j.jbiomech.2010.02.031

Journal of Biomechanics
Volume 43, Issue 9 , Pages 1696-1701 , 18 June 2010

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