Technical noteRanking the fracture toughness of thin mammalian soft tissues using the scissors cutting test
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Optimizing autoinjector devices using physics-based simulations and Gaussian processes
2023, Journal of the Mechanical Behavior of Biomedical MaterialsJ integral and local strain energy density approach to characterize the cracks in anisotropic hyperelastic skin type composite materials
2022, Theoretical and Applied Fracture MechanicsThe biomechanics of autoinjector-skin interactions during dynamic needle insertion
2022, Journal of BiomechanicsCitation Excerpt :For soft tissues such as skin, there exists data on the elastic properties (Limbert, 2017). The fracture properties for skin and other soft tissues have been estimated with scissor cutting tests (Pereira et al., 1997), trouser tear tests (Rivlin and Thomas, 1953; Shergold and Fleck, 2005; Pissarenko et al., 2020), and needle insertion re-insertion tests (Frick et al., 2001; Azar and Hayward, 2008; Barnett et al., 2016). We use experimental work from needle insertion tests to validate the model before conducting an extensive parametric investigation of skin-device interaction.
Fracture behaviour of human skin in deep needle insertion can be captured using validated cohesive zone finite-element method
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2021, International Journal of PharmaceuticsCitation Excerpt :These methods are not applicable for oral soft tissue due to size limitations. Oral soft tissue toughness can alternatively be determined using scissor-cutting tests (Pereira et al., 1997) or needle-insertion tests (Gokgol et al., 2012). The latter method was selected in this study due to its similarity to needle injection.
Impact of the mechanical properties of penetrated media on the injection characteristics of needle-free jet injection
2021, Experimental Thermal and Fluid Science