Journal of Biomechanics
Volume 32, Issue 12 , Pages 1297-1307 , December 1999

Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation

  • Melody A. Swartz

      Affiliations

    • Departments of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    • ,
  • Arja Kaipainen

      Affiliations

    • Department of Surgical Research, Children's Hospital, Boston, MA 02115, USA
    • ,
  • Paolo A. Netti

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114-2617, USA
    • ,
  • Christian Brekken

      Affiliations

    • Current address: Department of Physics, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114-2617, USA
    • ,
  • Yves Boucher

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114-2617, USA
    • ,
  • Alan J. Grodzinsky

      Affiliations

    • Department of Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    • ,
  • Rakesh K. Jain

      Affiliations

    • Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114-2617, USA
    • Corresponding Author InformationCorresponding author. Tel.: 1-617-726-4083; fax: 1-617-726-4172

,Accepted 19 May 1999.

References 

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  2. Aukland K, Reed RK. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiological Reviews. 1993;73:1–78
  3. Barry S, Aldis G. Comparison of models for flow induced deformation of soft biological tissue. Journal of Biomechanics. 1990;23:647–654
  4. Berk DA, Swartz MA, Leu AJ, Jain RK. Transport in lymphatic capillaries (II. Microscopic velocity measurement with fluorescence recovery after photobleaching). American Journal of Physiology. 1996;270:H330–337
  5. Berk DA, Yuan F, Leunig M, Jain RK. Fluorescence photobleaching with spatial Fourier analysis (measurement of diffusion in light-scattering media). Biophysical Journal. 1993;65:2428–2436
  6. Bert JL, Reed RK. Flow conductivity of rat dermis is determined by hydration. Biorheology. 1995;32:17–29
  7. Boucher Y, Jain RK. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors (implications for vascular collapse). Cancer Research. 1992;52:5110–5114
  8. Carslaw HS, Jaeger JC. Conduction of Heat in Solids. In: 2nd Edition. Oxford: The Clarendon Press; 1959;p. 64
  9. Frank EH, Grodzinsky AJ. Cartilage electromechanics — II. A continuum model of cartilage electrokinetics and correlation with experiments. Journal of Biomechanics. 1987;20:629–639
  10. Grodzinsky AJ. Electromechanical and physicochemical properties of connective tissue. Critical Reviews in Biomedical Engineering. 1983;9:133–199
  11. Guyton AC, Sheel K, Murphree D. Interstitial fluid pressure. III. Its effect on resistance to tissue fluid mobility. Circulation Research. 1966;19:412–419
  12. Leu AJ, Berk DA, Yuan F, Jain RK. Flow velocity in the superficial lymphatic network of the mouse tail. American Journal of Physiology. 1994;267:H1507–H1513
  13. Levick J. Flow through interstitium and other fibrous matrices. Quarterly Review of Experimental Physiology. 1987;72:409–438
  14. Mow, V.C., Kuei, S.C., Lai, W.M., Armstrong, C.G., 1980. Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiment. Journal of Biomechanical Engineering 102, 73–83.
  15. Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK. Macro- and microscopic fluid transport in living tissues (application to solid tumors). AIChE Journal. 1997;43:818–834
  16. Schmidt-Schönbein GW. Microlymphatics and lymph flow. Physiological Reviews. 1990;70:987–1028
  17. Simon BR. Multiphase poroelastic finite element models for soft tissue structure. Applied Mechanics Reviews. 1992;45:191–218
  18. Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK. Return of lymphatic function following flap transfer for acute lymphedema. Annals of Surgery. 1999;229:421–427
  19. Swartz MA, Berk DA, Jain RK. Transport in lymphatic capillaries (I. Macroscopic measurement using residence time distribution analysis). American Journal of Physiology. 1996;270:H324–329

PII: S0021-9290(99)00125-6

Journal of Biomechanics
Volume 32, Issue 12 , Pages 1297-1307 , December 1999

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